标题：Polymer-drug conjugates: recent progress on administration routes
作者：Pang, Xin; Yang, Xiaoye; Zhai, Guangxi
作者机构：[Pang, Xin; Yang, Xiaoye; Zhai, Guangxi] Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China.
通讯作者地址：[Zhai, GX]Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Peoples R China.
来源：EXPERT OPINION ON DRUG DELIVERY
关键词：intravenous route; ocular administration; oral route; polymer-drug; conjugates; pulmonary administration; routes of administration;; transdermal route
摘要：Introduction: Polymer-drug conjugates are an important part of polymer therapeutics. Recently, they have been used as an appealing platform for drug delivery. As a delivery vector, the route of administration performs a serious impact on the accessibility of drug molecules to their respective target site and therapeutic index. Furthermore, the physicochemical and biological properties of conjugates also correlate distinctly with the route of administration.; Areas covered: This article reviews the recent advances of polymer-drug conjugates as drug delivery systems through parenteral, enteral and topical routes. In particular, it mainly focuses on the classical and emerging routes such as injection, oral, transdermal, pulmonary and ocular routes using polymer-drug conjugates as delivery systems.; Expert opinion: Although polymer-conjugated drug delivery systems reported so far face severe shortcoming of being incomplete methodology and limited routes for administration (mostly concentrated in injection), some polymer carriers like poly(amidoamine) and hyaluronic acid still offer an appealing platform to deliver drug. Acquiring the particular characteristics of each polymer carrier, exploiting novel biodegradable polymer, expanding classical drug administration ways by emerging routes and developing a rational and systematic methodology to design administration routes will be the promising directions.