标题：Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E −/− Mice
作者：Lu W.; He X.; Su L.; Miao J.
作者机构：[Lu, W] Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, Chin 更多
通讯作者地址：[Miao, J] Institute of Developmental Biology, School of Life Science, Shandong UniversityChina;
来源：Journal of Cardiovascular Translational Research
关键词：API5; Apo E −/−; Atherosclerosis; CERNA1; lncRNA
摘要：Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Changes in atherosclerotic plaque composition will lead to acute coronary syndromes. Although the studies on the molecular mechanisms of long noncoding RNA (lncRNA) are in-depth in molecular and cell levels, the in vivo research which studied the knowledge about lncRNAs in the regulation of plaque composition is still sparse. In this study, in order to investigate how a new lncRNA, CERNA1, regulates the composition of atherosclerotic plaques, we overexpressed CERNA1 in apolipoprotein E −/− (Apo E −/− ) mice and analyzed the role of CERNA1 in atherosclerotic plaque stabilization. The results showed that CERNA1 inhibited the apoptosis of VSMCs and anti-inflammatory macrophages through increasing API5 level and further stabilized the atherosclerotic plaques. This discovery provided a novel therapeutic target for atherosclerosis. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.