标题：The Effect of Selenium on the Blood Radioimmunological Indexes Induced by High Dose of Fluorine
作者：Jiayong Zou;Xinying Lin;Jianchao Bian;Qiuli Zhu;Xiaoyan Zou
作者机构：[Zou, J] College of Public Health, Shandong University, JiNan-250012, Shandong Province, China;[ Lin, X] College of Public Health, Shandong University 更多
来源：Nature environment and pollution technology
关键词：Fluorine;Selenium;6-Keto-prostaglandin F_(1α);Thromboxane B_2;Endothelin-1
摘要：Endemic fluorosis is prevalent in China, which can seriously impair the bones, teeth and cardiovascular system. The study was intended to explore antagonism of selenium (Se) on high dose fluorine (F) inducing plasma 6-Keto-prostaglandin F_(1α),Thromboxane B_2 and Endothelin-1. Twenty male rabbits were randomly divided into 4 groups: High F group (NaF,100mg/L), Se group (Na_2SeO_3,1mg/L), High F + Se group (NaF, 100mg/L; Na_2SeO_3,1 mg/L) and Control group (without fluorine and selenium). The ear vein blood was collected for measurement of serum selenium and fluorine at the end of 0,3rd and 6th months. At the end of 6th months, plasma 6-Keto-prostaglandinF_(1α) (6-K-P), Thromboxane B_2(TXB_2) and Endothelin-1 (ET-1) were detected. Serum fluorine was increased in high F group and serum Se was increased in Se group. Plasma 6-K-P was decreased, while the plasma TXB_2 and ET-1 increased with the development of fluorosis. Compared with the high F group, the plasma 6-K-P was higher (p＜0.01), whereas plasma TXB_2 and ET-1 were lower (p＜0.01) in high F + Se group. The interaction showed that there was a significant antagonistic action of Se on decreased 6-K-P and increased TXB_2 induced by high dose fluorine. Our study showed that the Se may antagonize the adverse effects of high F.