标题：Possible benefit of splenectomy in liver transplantation for autoimmune hepatitis
作者：Yan-Tian Xu;De-Jie Liu;Fan-Ying Meng;Guang-Bing Li;Jun Liu
作者机构：[Xu, Y.-T] Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021 更多
通讯作者地址：[Liu, J]Shandong Univ, Shandong Prov Hosp, Dept Liver Transplantat & Hepatobiliary Surg, Jinan 250021, Peoples R China.
关键词：autoimmune hepatitis;liver transplantation;recurrence;splenectomy
摘要：Liver transplantation for autoimmune hepatitis (AIH) is usually successful with excellent long-term outcomes, but primary disease may recur. The recurrence of AIH is a significant cause of graft loss. This study was to analyze the effect of splenectomy in preventing All relapse. The clinical courses of 12 patients who had transplantation for AIH were analyzed retrospectively. All patients were subjected to transplantation for end-stage liver disease caused by chronic AIH. Based on the duration of immunosuppressive treatment before liver transplantation, simultaneous splenectomy was performed in ten patients. Two patients underwent liver transplantation without splenectomy, one of them developed recurrent All and died from graft failure caused by AIH relapse. However, no episode of AM recurrence was observed in patients who had undergone simultaneous splenectomy. Splenectomy might be an option to prevent AIH relapse in some patients with high risk factors.