标题:Parkinson\'s disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods
作者:Hou,Z.;Zhang,Z.;Meng,H.;Lin,X.;Sun,B.;Lei,H.;Fang,K.;Fang,F.;Liu,M.;Liu,S.
作者机构:[Hou, Z] Research Center for Sectional and Imaging Anatomy, Shandong University, School of Medicine, 44 Wen-hua Xi Road, Jinan, Shandong Province, 250 更多
通讯作者:Liu, SW
通讯作者地址:[Liu, SW]Shandong Univ, Sch Med, Res Ctr Sect & Imaging Anat, 44 Wen Hua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源:International Journal of Neuroscience
出版年:2014
卷:124
期:2
页码:125-132
DOI:10.3109/00207454.2013.825616
关键词:1H-MRS;Frontal and parietal cortices;Parkinson\'s disease
摘要:This study aims to investigate metabolic changes in frontal and parietal cortices in the 6-OHDA induced Parkinson\'s rats. Ratios of N-acetyl-aspartic acid/creatine (NAA/Cr), choline/creatine (Cho/Cr), and glumatic acid and glutamine glutaminic acid/creatine (Glx/Cr) of regions of interests (ROIs) in the frontal and parietal cortices, and the substantia nigra were analyzed. NAA/Cr, Cho/Cr and Glx/Cr in the frontal and parietal cortices in the lesion side did not show any significant differences two weeks after operation compared with the contralateral side (p > 0.05). NAA/Cr in the frontal cortex in the lesion side was significantly lower in the five weeks after operation; Cho/Cr remained normal; Glx/Cr increased (p < 0.05), and all ratios of parietal cortex were normal. In the eight weeks after operation, NAA/Cr in the frontal cortex in the lesion side was lower than that of the five weeks (p < 0.01), Cho/Cr still remained normal while Glx/Cr was higher than before (p < 0.01). Regarding the parietal cortex, NAA/Cr increased significantly, while Cho/Cr and Glx/Cr remained normal. In the 12 weeks after operation, NAA/Cr, Cho/Cr and Glx/Cr in frontal cortex were consistent with that of the eight weeks, while they remained at the normal level in parietal cortex. The NAA/Cr in the substantia nigra decreased and Cho/Cr increased significantly during 2-8 weeks, and remained at the same level during 8-12 weeks. There are metabolic disturbances in PD rats. The transient hyperfunction in the parietal cortex can be considered as a compensation for the dysfunction of the frontal cortex and substantia nigra.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892426749&doi=10.3109%2f00207454.2013.825616&partnerID=40&md5=3b992aa372f41350d2dd8a6a513adeb4
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