标题:B7-H3 in tumors: friend or foe for tumor immunity?
作者:Li, Gen; Quan, Yanchun; Che, Fengyuan; Wang, Lijuan
作者机构:[Li, Gen] Weifang Med Univ, Dept Neurol, Clin Med Coll, 7166 Baotong West St, Weifang City 261053, Shandong, Peoples R China.; [Li, Gen; Quan, Yanch 更多
通讯作者:Che, FY;Wang, LJ;Che, FY;Wang, LJ
通讯作者地址:[Che, FY; Wang, LJ]Shandong Univ, Linyi Peoples Hosp, Cent Lab, NB27,Eastern Part Jiefang Rd, Linyi 276000, Shandong, Peoples R China;[Che, FY]Shandon 更多
来源:CANCER CHEMOTHERAPY AND PHARMACOLOGY
出版年:2018
卷:81
期:2
页码:245-253
DOI:10.1007/s00280-017-3508-1
关键词:B7-H3; Expression; Co-stimulatory; Co-inhibitory; Tumor immunity; Cancer; immunotherapy
摘要:B7-H3 is a type I transmembrane co-stimulatory molecule of the B7 family. B7-H3 mRNA is widely distributed in most tissues; however, B7-H3 protein is not constitutively expressed. Few molecules have been shown to mediate the regulation of B7-H3 expression, and their regulatory mechanisms remain unexplored. Recently, TREM-like transcript 2 (TLT-2) has been identified as a potential receptor of B7-H3. However, TLT-2 may not be the only receptor of B7-H3, as B7-H3 has many contradictory roles. As a co-stimulatory molecule, B7-H3 increases the proliferation of both CD4+ and CD8+ T-cells and enhances cytotoxic T-cell activity. However, greatly increased T-cell proliferation and IL-2 levels have been observed in the absence of B7-H3. Thus far, it has been shown that various tumors test positive for B7-H3 expression and that B7-H3 levels correlate with tumor growth, invasion, metastasis, malignant stage, and recurrence rate. Furthermore, transfection of cells with a B7-H3 plasmid and treatment with monoclonal antibodies to block B7-H3 are the main immunotherapeutic strategies for cancer treatment. Several groups have generated anti-B7-H3 antibodies and observed tumor growth suppression in vitro and in vivo. Therefore, it is likely that B7-H3 plays an important role in cancer diagnosis and treatment, aside from its role as a co-stimulatory molecule.
收录类别:SCOPUS;SCIE
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040014434&doi=10.1007%2fs00280-017-3508-1&partnerID=40&md5=366deca21c2b416e5294628098cea947
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