标题：Biological Compound Capping of Silver Nanoparticle with the Seed Extracts of Blackcumin (Nigella sativa): A Potential Antibacterial, Antidiabetic, Anti-inflammatory, and Antioxidant
作者：Vijayakumar S.; Divya M.; Vaseeharan B.; Chen J.; Biruntha M.; Silva L.P.; Durán-Lara E.F.; Shreema K.;等 更多 作者机构：[Vijayakumar, S] Marine College, Shandong University, Weihai, 264209, China, Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechno 更多
通讯作者地址：[Vijayakumar, S] Marine College, Shandong UniversityChina;
来源：Journal of Inorganic and Organometallic Polymers and Materials
关键词：Anti-inflammatory; Antioxidant; Diabetes mellitus; Nigella sativa; Silver nanoparticles
摘要：It is a well explored facts that need of biosynthesized nanomaterials has emerged for its several advantages in biomedical applications and the search for potential biosynthesized-nanomaterials is still ongoing. In this study an attempt was made to meet the requirement of potential biosynthesized-silver nanoparticles using the aqueous seed extract of N. sativa (Bc-AgNPs). X-ray powder diffraction (XRD) confirms the biosynthesis of silver nanoparticle (supports the observation of UV–Vis spectroscopy) with face centred cubic structure. Fourier-transform infrared spectroscopy (FTIR) confirms the capping of the active ingredients of seed extract and further the average size of 34 nm was confirmed by high-resolution transmission electron microscopy (HR-TEM) and energy dispersive X-ray analysis (EDX) confirms the purity of Bc-AgNPs. Due to the capping of the active ingredients of seed extract, the Bc-AgNPs have shown significant antibacterial activity against Gram negative bacteria and at the lower concentration of 100 µg*ml−1 it has 89% scavenging activity against free radicals. A strong anti-inflammatory (membrane stabilization) activity towards RBCs (98% at 100 µg*ml−1) was recorded when compared to the positive control (aceclofenac). In addition to the previous activities, a greater inhibition of carbohydrate hydrolyzing enzymes such as α-amylase, α-glucosidase and DPP-IV highlighted the antidiabetic potential of these green synthesized AgNPs. Overall, the efficient bioactivities of Bc-AgNPs advocates its future potential in biomedical products. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.