标题：Supramolecular hydrogels facilitated by α-cyclodextrin and silicone surfactants and their use for drug release
作者：Tong, Lu ;Yang, Yingjie ;Luan, Xiaoyu ;Shen, Jinglin ;Xin, Xia
作者机构：[Tong, Lu ;Yang, Yingjie ;Luan, Xiaoyu ;Xin, Xia ] National Engineering Technology Research Center for Colloidal Materials, Shandong University, Shand 更多
来源：Colloids and Surfaces A: Physicochemical and Engineering Aspects
摘要：Supramolecular hydrogels were facilitated by α-cyclodextrin (α-CD) and three silicone surfactants named S1E8, S1E19 and S2E38, respectively. Influences of the molecular structure and concentration of the silicone surfactants on the formation of hydrogels and their stabilities were investigated. The hydrogels were characterized by phase behavior study and various techniques. The results indicated that the balance between the hydrophilicity and the hydrophobicity of the silicone surfactants is crucial for the formation and high stability of the hydrogels. S2E38, which has two poly-(ethylene oxide) chains, exhibits a stronger ability to form hydrogels than S1E8 and S1E19 do. Moreover, in vitro study using doxorubicin (DOX) as a model anticancer drug shows that α-CD/silicone surfactant hydrogels can be used as injectable carriers for controlled drug release.
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