标题:Efficient drug discovery by rational lead hybridization based on crystallographic overlay
作者:Zhang, Shuo; Zhang, Jian; Gao, Ping; Sun, Lin; Song, Yuning; Kang, Dongwei; Liu, Xinyong; Zhan, Peng
作者机构:[Zhang, Shuo; Zhang, Jian; Gao, Ping; Sun, Lin; Kang, Dongwei; Liu, Xinyong; Zhan, Peng] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Che 更多
通讯作者:Kang, DW;Liu, XY;Zhan, P
通讯作者地址:[Kang, DW; Liu, XY; Zhan, P]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandon 更多
来源:DRUG DISCOVERY TODAY
出版年:2019
卷:24
期:3
页码:805-813
DOI:10.1016/j.drudis.2018.11.021
摘要:In this review, we provide an overview of recent applications of crystallographic overlay-based molecular structure hybridization of lead compounds as a rational strategy for efficient drug discovery, with selected examples, and briefly discuss its advantages compared with other ligand-based methodologies.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058377164&doi=10.1016%2fj.drudis.2018.11.021&partnerID=40&md5=f26590d2ee570d201e481acb0b6a42dc
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