标题：Integrin alpha v beta 8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-beta 1
作者：Zhou, Mingliang; Niu, Jun; Wang, Jinshen; Gao, Huijie; Shahbaz, Muhammad; Niu, Zhengchuan; Li, Zequn; Zou, Xueqing; Liang, Benjia
作者机构：[Zhou, Mingliang; Wang, Jinshen; Liang, Benjia] Shandong First Med Univ, Shandong Prov Hosp, Dept Gastrointestinal Surg, Jinan 250021, Shandong, Peopl 更多
通讯作者地址：Liang, BJ (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Gastrointestinal Surg, Jinan 250021, Shandong, Peoples R China.
来源：JOURNAL OF CANCER
关键词：integrin alpha v beta 8; colon cancer; prognostic factors; cell; invasiveness; TGF-beta 1
摘要：Integrin alpha v beta 8 expressed on tumor cells executes crucial regulatory functions during cell adhesion in the tumor microenvironment and supports the activation of TGF-beta 1. This study aimed to investigate the expression of integrin alpha v beta 8 and its clinical significance in colon cancer, in addition to its influence on the invasion and migration of cancer cells. Our results showed that integrin alpha v beta 8 was an indicator of progression and poor prognosis in patients with colon cancer. Moreover, integrin alpha v beta 8 significantly promoted the invasion and migration of colon cancer cells by the activation of TGF-beta 1 and upregulation of metalloproteinase-9. Furthermore, suppression of integrin alpha v beta 8 was found to inhibit the growth of colon cancer in vivo. Our results indicate that integrin alpha v beta 8 promotes tumor invasiveness and the migration of colon cancer through TGF-beta 1 activation and is a potential prognostic biomarker. This study may provide clues to further understand the manner in which the tumor microenvironment mediates the development of colon cancer and develop strategies for novel therapeutic targets in the prevention and treatment of colon cancer.