标题：Differential expression of complement proteins in cerebrospinal fluid from active multiple sclerosis patients.
作者：Li Y;Qin Z;Yang M;Qin Y;Lin C;Liu S
作者机构：[Li, Y] Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan 250012, Shandong, China;[ Qi 更多
通讯作者地址：[Liu, SL]Shandong Univ, Inst Biochem & Mol Biol, Sch Med, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
来源：Journal of Cellular Biochemistry
关键词：MULTIPLE SCLEROSIS; 2-D DIGE; CEREBROSPINAL FLUID; COMPLEMENT
摘要：Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex immunopathogenesis. Using the 2-D DIGE technology, we separate CSF proteins from patients with active MS and control subjects. Three of the seven differential proteins identified were related with complement system, and the network analysis of the differential proteins revealed complement activation involvement in active MS. Complement C4b (gamma chain) was confirmed elevated by performing western blotting analysis (P < 0.01). The present results are an independent quantitative proteomic measure in CSF from active MS patients. The differential expression of the complement C4b and related proteins in CSF provides potential biomarkers as well as evidence for the involvement of complement activation in the pathogenesis of MS disease.