标题:Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation
作者:Dziewulska,D.;Doi,H.;Fasano,A.;Erro,R.;Fatehi,F.;Fekete,R.;Gatto,E.M.;Pablos,E.G.;Lehn,A.;Miyajima,H.;Piperno,A.;Pellechia,M.T.;
作者机构:[Dziewulska, D] Department of Neurology, Medical University of Warsaw, Warsaw, Poland, Department of Experimental and Clinical Neuropathology, Mossako 更多
通讯作者:McNeill, A
通讯作者地址:[McNeill, A]Birmingham Womens Hosp, Reg Clin Genet Unit, Mindelsohn Way, Birmingham B15 2TG, W Midlands, England.
来源:Acta Neuropathologica
出版年:2013
卷:126
期:1
页码:151-153
DOI:10.1007/s00401-013-1136-3
摘要:Neurodegenerative disorders with brain iron accumulation (NBIA) are a clinically and genetically heterogeneous group of neurodegenerative diseases featuring excessive brain iron deposition [2]. Iron deficient mice display impaired olfactory behaviour and chronic exposure to airborne iron particles is associated with hyposmia [4]. We hypothesised that dysregulated brain iron metabolism in NBIA might be associated with hyposmia. We tested olfactory function in a group of NBIA patients and performed histological examination of olfactory tissue from patients with NBIA and a mouse NBIA model for iron deposition.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879567051&doi=10.1007%2fs00401-013-1136-3&partnerID=40&md5=a23ebce51f56c68dd213d32a3d13b354
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