标题:Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation
作者:Dziewulska,D.;Doi,H.;Fasano,A.;Erro,R.;Fatehi,F.;Fekete,R.;Gatto,E.M.;Pablos,E.G.;Lehn,A.;Miyajima,H.;Piperno,A.;Pellechia,M.T.;
作者机构:[Dziewulska, D] Department of Neurology, Medical University of Warsaw, Warsaw, Poland, Department of Experimental and Clinical Neuropathology, Mossako 更多[Dziewulska, D] Department of Neurology, Medical University of Warsaw, Warsaw, Poland, Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland;[ Doi, H] Department of Clinical Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan;[ Fasano, A] Department of Neurology, Catholic University, Rome, Italy;[ Erro, R] Department of Neurological Sciences, University Federico II Naples, Naples, Italy;[ Fatehi, F] Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;[ Fekete, R] Department of Neurology, New York Medical College, New York, United States;[ Gatto, E.M] Movement Disorders and Parkinson's Disease Department, Instituto de Neurociencias Buenos Aires-INEBA, Buenos Aires, Argentina;[ Pablos, E.G] Complejo Hospitalario San Luis Palencia Carretera de Burgos, Palencia, Spain;[ Lehn, A] Department of Neurology, Princess Alexandra Hospital, Brisbane, Australia;[ Miyajima, H] First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan;[ Piperno, A] Department of Health Sciences, S.Gerardo Hospital, University of Milano-Bicocca, Monza, Italy;[ Pellechia, M.T] Center for Neurodegenerative Diseases, University of Salerno, Salerno, Italy;[ Wu, Y.-R] Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan;[ Yoshida, K] Division of Neurogenetics, Department of Brain Disease Research, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;[ Zarruk, J.G] Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Canada;[ Jingli, S] Department of Neurology, Qilu Hospital, Shandong University, Jinan, China;[ Schrag, A] Department of Clinical Neurosciences, Institute of Neurology, Royal Free Hospital, London, United Kingdom;[ McNeill, A] Regional Clinical Genetics Unit, Birmingham Women's Hospital, Mindelsohn Way, Birmingham B15 2TG, United Kingdom 收起 通讯作者:McNeill, A
通讯作者地址:[McNeill, A]Birmingham Womens Hosp, Reg Clin Genet Unit, Mindelsohn Way, Birmingham B15 2TG, W Midlands, England.
来源:Acta Neuropathologica
出版年:2013
卷:126
期:1
页码:151-153
DOI:10.1007/s00401-013-1136-3
摘要:Neurodegenerative disorders with brain iron accumulation (NBIA) are a clinically and genetically heterogeneous group of neurodegenerative diseases featuring excessive brain iron deposition [2]. Iron deficient mice display impaired olfactory behaviour and chronic exposure to airborne iron particles is associated with hyposmia [4]. We hypothesised that dysregulated brain iron metabolism in NBIA might be associated with hyposmia. We tested olfactory function in a group of NBIA patients and performed histological examination of olfactory tissue from patients with NBIA and a mouse NBIA model for iron deposition.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879567051&doi=10.1007%2fs00401-013-1136-3&partnerID=40&md5=a23ebce51f56c68dd213d32a3d13b354