标题:The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia.
作者:Yan HM;Zhao J;Ma DZ;Wang H;Wang J;Wang ZH;Li L;Zhang Y;Zhang W;Zhong M
作者机构:[Yan, H.-M] Qilu Hospital, Shandong University, Department of Cardiology, No. 107 Wenhua West Road, Jinan, 250012, China;[ Zhao, J] Qilu Hospital, Sha 更多
通讯作者:Zhong, M
通讯作者地址:[Zhong, M]Shandong Univ, Qilu Hosp, Dept Cardiol, 107 Wenhua W Rd, Jinan 250012, Peoples R China.
来源:Expert opinion on pharmacotherapy
出版年:2011
卷:12
期:10
页码:1463-1471
DOI:10.1517/14656566.2011.583238
关键词:endothelial function; hypercholesterolemia; oxidative stress;; pitavastatin calcium
摘要:OBJECTIVE: To investigate whether endothelial function can be improved by the treatment of pitavastatin calcium via its antioxidant properties in hypercholesteremia patients. METHODS: Forty patients with hypercholesteremia were randomized to receive pitavastatin calcium 1 or 2 mg/day for 8 weeks. Among them, four people were lost in the follow-up period. Before and after treatment, clinical and biochemical characteristics, markers of oxidative stress (plasma 8-iso-prostaglandin F(2alpha) and serum gp91phox) were determined and concomitantly endothelium-dependent brachial artery flow-mediated dilation (FMD) was measured by ultrasound examination. Thirty healthy subjects were chosen as controls. RESULTS: For individuals with hypercholesteremia, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and serum gp91phox were significantly increased (p<0.001 for all) and plasma 8-iso-prostaglandinF2alpha (8-iso-PGF2alpha) was significantly higher (p<0.05), while FMD was obviously impaired (p<0.001). Total cholesterol, LDL-C and serum gp91phox were significantly reduced (p<0.001 for all), plasma 8-iso-PGF2alpha was lower and FMD was significantly improved after pitavastatin calcium treatment compared with those before treatment in any group (p<0.05 for both). However, there was no significant difference between the 1-mg and 2-mg pitavastatin calcium groups post-therapy. CONCLUSIONS: Endothelial dysfunction induced by hypercholesteremia can be ameliorated by pitavastatin calcium treatment, which occurs in part through its antioxidative properties.
收录类别:SCOPUS;SCIE
WOS核心被引频次:5
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958744386&doi=10.1517%2f14656566.2011.583238&partnerID=40&md5=96b7c359a022371e1bd37cddd47ae16d
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