标题:Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO3 Nanocomposites for Synergistic Oncotherapy
作者:Chang M.; Hou Z.; Jin D.; Zhou J.; Wang M.; Wang M.; Shu M.; Ding B.;等 更多
作者机构:[Chang, M] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 更多
通讯作者:Hou, Z(zyhou@gzhmu.edu.cn)
通讯作者地址:[Hou, Z] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, State Key Lab 更多
来源:Advanced Materials
出版年:2020
DOI:10.1002/adma.202004647
关键词:bio-decomposition; colorectal tumor microenvironment; Cu 2O@CaCO 3; metabolism; synergistic oncotherapy
摘要:Rational design of tumor microenvironment (TME)-activated nanocomposites provides an innovative strategy to construct responsive oncotherapy. In colorectal cancer (CRC), the specific physiological features are the overexpressed endogenous H2S and slightly acidic microenvironment. Here, a core–shell Cu2O@CaCO3 nanostructure for CRC “turn-on” therapy is reported. With CaCO3 responsive to pH decomposition and Cu2O responsive to H2S sulfuration, Cu2O@CaCO3 can be triggered “on” into the therapeutic mode by the colorectal TME. When the CaCO3 shell decomposes and releases calcium in acidic colorectal TME, the loss of protection from the CaCO3 shell exposes the Cu2O core to be sulfuretted by H2S to form metabolizable Cu31S16 nanocrystals that gain remarkably strong near-infrared absorption. After modifying hyaluronic acid, Cu2O@CaCO3 can achieve synergistic CRC-targeted and TME-triggered photothermal/photodynamic/chemodynamic/calcium-overload-mediated therapy. Moreover, it is found that the generation of hyperthermia and oxidative stress from Cu2O@CaCO3 nanocomposites can efficiently reprogram the macrophages from the M2 phenotype to the M1 phenotype and initiate a vaccine-like immune effect after primary tumor removal, which further induces an immune-favorable TME and intense immune responses for anti-CD47 antibody to simultaneously inhibit CRC distant metastasis and recurrence by immunotherapy. © 2020 Wiley-VCH GmbH
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091025473&doi=10.1002%2fadma.202004647&partnerID=40&md5=1208cfcc5cc67f58e0d563a5d3f9f1aa
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