标题:Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT
作者:Su Zhan;Wu Fengyu;Hu Weiyu;Liu Xiaodan;Wu Shaoling;Feng Xianqi;Cui Zhongguang;Yang Jie;Wang Zhenguang;Guan Hongzai;Zhao Hongguo;Wang Wei;Zhao Chunting 更多
作者机构:[Su, Z] Department of Haematology, Qilu Hospital, Shandong University, Jinan, 250012, China, Department of Haematology, The Affiliated Hospital of Qin 更多
通讯作者:Peng, J(junpeng88@sina.com.cn)
通讯作者地址:[Peng, J]Shandong Univ, Qilu Hosp, Dept Haematol, Jinan 250012, Shandong, Peoples R China;[Zhao, CT]Qingdao Univ, Dept Haematol, Affiliated Hosp, Qing 更多
来源:医学前沿
出版年:2017
卷:11
期:3
页码:440-444
DOI:10.1007/s11684-017-0523-x
关键词:Philadelphia chromosome;acute myeloid leukemia;mass;osteolysis;positron emission tomography
摘要:Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia.As a myeloid neoplasm,rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions.In this paper,we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain,fever,fatigue,emaciation,and splenomegaly.18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion,multiple soft tissue neoplasms with high 18F-FDG uptake,and lytic bone lesions.Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker.For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities,a diagnosis of Philadelphia-positive acute myeloid leukemia was made,although the type (de novo or blast crisis) remained unclear.
收录类别:CSCD;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019718743&doi=10.1007%2fs11684-017-0523-x&partnerID=40&md5=1fafe3e5d9a9ab255009091dba28fb60
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