标题:Development of RGD-Functionalized PEG-PLA Micelles for Delivery of Curcumin
作者:Zhao, Liyan; Yang, Chunfen; Dou, Jinfeng; Xi, Yanwei; Lou, Hongxiang; Zhai, Guangxi
作者机构:[Zhao, Liyan; Yang, Chunfen; Dou, Jinfeng; Xi, Yanwei; Zhai, Guangxi] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R Chin 更多
通讯作者:Zhai, Guangxi
通讯作者地址:[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China.
来源:JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
出版年:2015
卷:11
期:3
页码:436-446
DOI:10.1166/jbn.2015.1919
关键词:Curcumin; Micelles; RGD; Targeting; PEG-PLA
摘要:Curcumin (Cur), a hydrophobic polyphenolic compound, possesses a wide range of biological activities. However, its prominent application in cancer treatment is limited due to low aqueous solubility and rapid metabolism. Recently, micelle-based drug delivery system has been proven to be an attractive alternative for poorly soluble drugs. In order to improve the application of Cur as an anti-cancer agent, in this study, we synthesized the alpha v beta 3 integrin-targeted peptide (RGD) functionalized polymer (RGD-PEG-PLA). The RGD conjugated Cur loaded micelles (Cur-RPP) were prepared using the thin-film hydration method with modification and the preparation process was optimized with a central composite design. The obtained Cur-RPP presented spherical shape with a particle size of 20 nm and high drug loading (4.70%). Compared with the Cur propylene glycol solution, the in vitro release of Cur from the prepared micelles showed the sustained-release property. Cellular uptake of Cur-RPP was found to be higher than that of non-RGD modified micelles due to the binding effect between alpha v beta 3 integrin and RGD in human umbilical vein endothelial cells (HUVEC) and mouse melanoma cell lines (B16). In B16 tumor-bearing mice, Cur-RPP showed the stronger inhibiting effect on growth of tumor compared with non-RGD modified micelles. It could be concluded from these results that the RGD modified micelles might be a potential carrier for Cur.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:15
Scopus被引频次:16
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918585434&doi=10.1166%2fjbn.2015.1919&partnerID=40&md5=628bac455760af24fbf01f9ada9f44f3
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