标题：Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components
作者：Zhou, Li; Luo, Cheng; Yin, Jiawei; Zhu, Yalun; Li, Peiyun; Chen, Sijing; Sun, Taoping; Xie, Manling; Shan, Zhilei; Cao, Benfeng; H 更多 作者机构：[Zhou, Li; Luo, Cheng; Yin, Jiawei; Zhu, Yalun; Li, Peiyun; Chen, Sijing; Sun, Taoping; Shan, Zhilei; Cao, Benfeng; Hu, Xueting; Yang, Wei; Li, Xiaoqi 更多
通讯作者地址：Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Sa, Wuhan, 更多
来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
摘要：The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine the associations of plasma selenium concentrations and selenoprotein P rs7579 polymorphism with MetS, a case-control study of 1279 MetS cases and 1279 sex- and age- (+/- 2 years) matched controls was conducted based on the baseline data of the Tongji-Ezhou Cohort study. Plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry. MetS was defined using the definition of the Joint Interim Statement, adjusted for the Chinese population. In addition, the rs7579 polymorphism was genotyped by the Agena MassARRAY System. Plasma selenium concentrations in the MetS group were higher than in the control group (93.88 mu g/L (83.17-107.41) vs. 92.66 mu g/L (82.36-103.53), P<0.05). Compared with quartile 4 (>= 103.53 mu g/L), the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) associated with MetS were 0.79 (0.59-1.06) for quartile 1 (mu g/L), 0.75 (0.56-1.01) for quartile 2 (82.37-92.66 mu g/L), and 0.61 (0.45-0.83) for quartile 3 (92.67-103.52 mu g/L). The cubic spline analyses revealed a U-shaped association between plasma selenium and MetS, with the lowest risk at around 93.69 mu g/L. Moreover, in cubic spline analyses, plasma selenium showed U-shaped associations with central obesity and high blood pressure, positive associations with hypertriglyceridemia and hyperglycemia, and a negative association with low high-density lipoprotein cholesterol. Additionally, both the GA and GA+AA genotype carriers were associated with increased ORs of MetS comparing with the GG genotype carriers. Our findings suggested a U-shaped association between plasma selenium and MetS and diverse associations between plasma selenium and components of MetS. Furthermore, our study found that the A allele of rs7579 was associated with higher odds of MetS. Further studies are needed to confirm our findings and elucidate the underlying mechanisms.