标题:Ansavaricins A-E: five new streptovaricin derivatives from Streptomyces sp S012
作者:Zhang, Zhiqiang; Zhang, Juanli; Song, Rentai; Guo, Zhixing; Wang, Haoxin; Zhu, Jing; Lu, Chunhua; Shen, Yuemao
作者机构:[Zhang, Zhiqiang; Guo, Zhixing; Lu, Chunhua; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 更多
通讯作者:Shen, Yuemao
通讯作者地址:[Shen, Y]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China;[Shen, Y]Shando 更多
来源:RSC ADVANCES
出版年:2017
卷:7
期:10
页码:5684-5693
DOI:10.1039/c6ra27405f
摘要:Five new polyketides of the ansamycin class, named ansavaricins A-E (1-5), together with three known streptovaricins 6-8, were isolated from the Streptomyces sp. S012 strain. The structures of 1-8 were determined by analysis of the 1D and 2D NMR spectroscopic and high-resolution ESIMS data, which showed plentiful structural variations in the naphthoquinoid moieties and ansa chains of ansavaricins AE. Ansavaricins A-E showed almost no obvious toxicity to the test Gram positive and negative bacteria. However, compounds 5, 6 and 7 significantly inhibited the secretion of SPI-1 effectors of Salmonella enterica serovar Typhimurium, indicating a potential in the development of antivirulence antibacterial drugs.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010676751&doi=10.1039%2fc6ra27405f&partnerID=40&md5=1aba199b32f57a3ede9106b566b3e38c
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