标题：Ansavaricins A-E: five new streptovaricin derivatives from Streptomyces sp S012
作者：Zhang, Zhiqiang; Zhang, Juanli; Song, Rentai; Guo, Zhixing; Wang, Haoxin; Zhu, Jing; Lu, Chunhua; Shen, Yuemao
作者机构：[Zhang, Zhiqiang; Guo, Zhixing; Lu, Chunhua; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 更多
通讯作者地址：[Shen, Y]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China;[Shen, Y]Shando 更多
摘要：Five new polyketides of the ansamycin class, named ansavaricins A-E (1-5), together with three known streptovaricins 6-8, were isolated from the Streptomyces sp. S012 strain. The structures of 1-8 were determined by analysis of the 1D and 2D NMR spectroscopic and high-resolution ESIMS data, which showed plentiful structural variations in the naphthoquinoid moieties and ansa chains of ansavaricins AE. Ansavaricins A-E showed almost no obvious toxicity to the test Gram positive and negative bacteria. However, compounds 5, 6 and 7 significantly inhibited the secretion of SPI-1 effectors of Salmonella enterica serovar Typhimurium, indicating a potential in the development of antivirulence antibacterial drugs.