标题：ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-alpha and NF-kappa B P65
作者：Li, Jing-kun; Cheng, Lei; Zhao, Yun-peng; Guo, Ying-jun; Liu, Yi; Zhang, Wei; Wang, Shuai-shuai; Zhang, Yuan-qiang; Pan, Xin; Nie, L 更多 作者机构：[Li, Jing-kun; Cheng, Lei; Zhao, Yun-peng; Pan, Xin; Nie, Lin] Shandong Univ, Qilu Hosp, Dept Orthoped Surg, Jinan 250012, Shandong, Peoples R China.; 更多
通讯作者地址：[Pan, X]Shandong Univ, Qilu Hosp, Dept Orthoped Surg, Jinan 250012, Shandong, Peoples R China.
来源：MEDIATORS OF INFLAMMATION
摘要：ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-alpha and NF-kappa B signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-alpha, and Phospho-NF-kappa B in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-alpha, and Phospho-NF-kappa B was significantly upregulated in ONFH patients' articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-alpha and Phospho-NF-kappa B P65 in cartilage, which may imply its association with cartilage destruction of ONFH.