标题:ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-alpha and NF-kappa B P65
作者:Li, Jing-kun; Cheng, Lei; Zhao, Yun-peng; Guo, Ying-jun; Liu, Yi; Zhang, Wei; Wang, Shuai-shuai; Zhang, Yuan-qiang; Pan, Xin; Nie, L 更多
作者机构:[Li, Jing-kun; Cheng, Lei; Zhao, Yun-peng; Pan, Xin; Nie, Lin] Shandong Univ, Qilu Hosp, Dept Orthoped Surg, Jinan 250012, Shandong, Peoples R China.; 更多
通讯作者:Pan, X
通讯作者地址:[Pan, X]Shandong Univ, Qilu Hosp, Dept Orthoped Surg, Jinan 250012, Shandong, Peoples R China.
来源:MEDIATORS OF INFLAMMATION
出版年:2015
DOI:10.1155/2015/196702
摘要:ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-alpha and NF-kappa B signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-alpha, and Phospho-NF-kappa B in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-alpha, and Phospho-NF-kappa B was significantly upregulated in ONFH patients' articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-alpha and Phospho-NF-kappa B P65 in cartilage, which may imply its association with cartilage destruction of ONFH.
收录类别:SCIE
WOS核心被引频次:1
资源类型:期刊论文
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