标题：MiR-150 inhibits hypoxia-induced autophagy in oral squamous carcinoma by negatively regulating BNIP3
作者：Cui, Yan-Jun; Liu, Chao; Pang, Fa-Wei; Liu, Guang-Ping; Zhou, Jian-Hua; Shi, Xiao-Ming; Huang, Sheng-Yun; Zhang, Dong-Sheng
作者机构：[Cui, Yan-Jun; Pang, Fa-Wei; Liu, Guang-Ping; Zhou, Jian-Hua; Zhang, Dong-Sheng] Shandong Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Jinan, P 更多
通讯作者：Huang, SY;Zhang, DS
通讯作者地址：[Huang, SY; Zhang, DS]Shandong Univ, Dept Oral & Maxillofacial Surg, Shandong Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
关键词：miR-150; autophagy; oral squamous carcinoma; BNIP3
摘要：Oral squamous cell carcinoma (OSCC) is a malignant solid tumor characterized by hypoxia. Autophagy is considered to play a protective role in cancer cells under hypoxia. A variety of microRNAs (miRNAs) that play a critical role in tumorigenesis have been identified. However, the underlying mechanisms of miR-150 in OSCC development remain unclear. In this study, we observed decreased downregulated expression of miR-150 in association with increased expression of BNIP3 in CAL-27 cells under hypoxia. Hypoxia induced the initiation of the BNIP3-mediated autophagic process, and overexpression of miR-150 inhibited hypoxia-induced autophagy. In addition, we demonstrated that miR-150 inhibited autophagy by negatively regulating the expression of the BNIP3 gene. Collectively, our study identified miR-150 as a key modulator of autophagy by inhibiting BNIP3 in OSCC cells.