标题:CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma
作者:Zhang, Tengyue; Ma, Kelong; Huang, Jin; Wang, Shitang; Liu, Yabei; Fan, Gaofei; Liu, Miao; Yang, Guangshan; Wang, Cheng; Fan, Pingsh 更多
作者机构:[Zhang, Tengyue; Fan, Pingsheng] Shandong Univ, Sch Clin Med, Jinan 250100, Shandong, Peoples R China.; [Zhang, Tengyue; Huang, Jin; Liu, Yabei; Fan 更多
通讯作者:Fan, PS;Fan, PS;Wang, C
通讯作者地址:[Fan, PS]Shandong Univ, Sch Clin Med, Jinan 250100, Shandong, Peoples R China;[Fan, PS]Anhui Med Univ, Canc Hosp Anhui Prov, Prov Hosp, Hefei 230032, 更多
来源:ONCOTARGET
出版年:2017
卷:8
期:66
页码:110052-110063
DOI:10.18632/oncotarget.22123
关键词:hepatocellular carcinoma (HCC); verapamil (VER); doxorubicin (ADM);; CDKN2B; chemotherapy resistance
摘要:In this study, we explored the function and mechanism of CDKN2B genes in verapamil (VER)-induced reversal of resistance to doxorubicin (ADM) chemotherapy in hepatocellular carcinoma (HCC). We examined 4 HCC cell lines and found that the expression levels of CDKN2B genes correlated with the level of apoptosis induced by ADM+VER. Overexpression of CDKN2B genes promoted apoptosis in cells treated with VER+ADM. CDKN2B knockdown using siRNA weakened the effect of ADM+VER, indicating that ADM+VER promotes HCC cell apoptosis and that CDKN2B genes participate in VER-mediated promotion in tumor cell apoptosis. Future research will further explore the functional mechanism, and the associated signal transduction pathways via which CDKN2B affects HCC drug resistance.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038080897&doi=10.18632%2foncotarget.22123&partnerID=40&md5=46bc6cea4728b7b3b776b3b8f3f930a8
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