标题：Vitamin E: supplement versus diet in neurodegenerative diseases
作者：Shen, Liang; Ji, Hong-Fang
作者机构：[Shen, Liang; Ji, Hong-Fang] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China.
通讯作者地址：[Shen, L]Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China.
来源：TRENDS IN MOLECULAR MEDICINE
摘要：Contradicting outcomes have been observed in numerous studies investigating the benefits of vitamin E supplements in the context of neurodegenerative diseases. By reviewing epidemiological studies and clinical trials, it is found that dietary intake of vitamin E exhibits beneficial effects on neurodegeneration, whereas alpha-tocopherol supplements failed in most interventional trials. Potential reasons for why alpha-tocopherol supplements exhibit disappointing effects, especially compared with dietary intake, are put forward and implications for future studies are discussed.