标题：Clinical characteristics of early neuroendocrine carcinoma in stomach A case report and review of literature
作者：Zhu, Xiaolong; Jing, Haiyan; Yao, Takashi
作者机构：[Zhu, Xiaolong] Shandong Univ, Shandong Prov Hosp, Dept Cardiac Surg, Jinan 250021, Shandong, Peoples R China.; [Jing, Haiyan] Shandong Univ, Shando 更多
通讯作者：Jing, HY;Yao, T
通讯作者地址：[Jing, HY]Shandong Univ, Shandong Prov Hosp, Dept Pathol, Jinan 250021, Shandong, Peoples R China;[Yao, T]Juntendo Univ, Grad Sch Med, Dept Human Path 更多
关键词：early gastric neuroendocrine carcinoma; endoscopic submucosal; dissection; mixed adenoneuroendocrine carcinoma; prognosis; upper; gastrointestinal endoscopy
摘要：Introduction: Gastric neuroendocrine carcinoma (NEC) is rare. It is considered to be aggressive and has a poor prognosis since the diagnosis is usually made at its advanced stage. However, the survival rate is increased in some early gastric NECs. This study showed a case and reviewed the clinical characteristics of early NECs in stomach.; Patient concerns: A 38-year-old man displayed no symptoms and underwent the gastric endoscopy test for his health examination, which showed a red slightly depressed lesion 1.0cm in size on the lesser curvature of gastric cardia. Magnifying endoscopy with narrow-band imaging (NBI) revealed a clear demarcation and an irregular mesh in vessels within the depressed area. The background mucosa was negative for atrophic gastritis and Helicobacter Pylori infection. A contrast-enhanced computed tomography (CT) scan disclosed no obvious thickening of stomach and lymphadenopathy. Blood tests and physical examination were unremarkable. He had not received any surgical treatment and denied a family history of cancer and any genetic disorders. The pathologic result of biopsy from the lesion was suspicious of superficial carcinoma. Then endoscopic submucosal dissection (ESD) was performed.; Diagnosis: Gastric NEC G3 in the early stage (T1aN0M0).; Interventions: Concerning this patient's situation, we considered the ESD as a curable treatment. And no radical surgery or adjuvant chemotherapy was arranged.; Outcomes: The patient is doing well and displays no recurrence for 11months, who is still in follow-up.; Lessons subsections as per style: The early diagnosis and effective treatment by endoscopy would contribute to improve the prognosis of gastric NECs.