标题：SYNTHESIS OF NITROGEN BRIDGEHEAD HETEROCYCLES WITH PHOSPHONATES VIA A NOVEL TANDEM PROCESS
作者：Ya-Fei Xie;Yan-Qing Ge;Lei Feng
作者机构：School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, P. R. China.;School of Chemistry and
来源：Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry
摘要：A novel and efficient method was developed for the synthesis of nitrogen bridgehead heterocycles with phosphonates. Nitrogen containing five-membered heterocyclic aldehyde and diethyl 3-bromoprop-l-enylphosphonate were used as substrates. Bridgehead nitrogen-containing arylphosphonates were obtained via one-pot reaction including four steps: S_n2, deprotonation followed by electron flow, nucleophic additon and elimination of water.