标题:Facile Synthesis, Single-Crystal Structure, and Biological Evaluation of Novel Pyrazolo[5,1-d][1,2,5]triazepin-4-ones
作者:Zheng, Liang-Wen; Xuan, Hong-Zhuan; Liu, Ying-Rui; Zhao, Bao-Xiang; Liu, Jin-Ting; Miao, Jun-Ying
作者机构:[Zheng, Liang-Wen; Liu, Ying-Rui; Zhao, Bao-Xiang; Liu, Jin-Ting] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China. 更多
通讯作者:Zhao, BX
通讯作者地址:[Zhao, BX]Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.
来源:HELVETICA CHIMICA ACTA
出版年:2012
卷:95
期:1
页码:134-143
DOI:10.1002/hlca.201100249
关键词:Pyrazolo[5; 1-d][1; 2; 5]triazepin-4-ones; Anti-apoptotic activity;; X-Ray crystallography
摘要:A facile ring-enlargement reaction of 2,6-diphenyl-4H-pyrazolo[5,1-c][1,4]oxazin-4-one is described, generating the pyrazolo[5,1-d][1,2,5]triazepin-4-ones in good yields. Structures of the prepared compounds were determined on the basis of IR, 1H- and 13C-NMR, and HR-MS data. Moreover, the molecular structure was confirmed by the X-ray crystal-structure analysis of one compound that was prone to crystallization. Preliminary biological evaluation showed that the compounds 2e2h promote the viability and inhibit the apoptosis of vascular endothelial cells at low concentration.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862916029&doi=10.1002%2fhlca.201100249&partnerID=40&md5=9fe9dc15090a168320d2b26da5a1defa
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