标题：Bioactivity of micropatterned TiO2 nanotubes fabricated by micro-milling and anodic oxidation
作者：Wang, Guisen ;Wan, Yi ;Ren, Bing ;Liu, Zhanqiang
作者机构：[Wang, Guisen ;Wan, Yi ;Ren, Bing ;Liu, Zhanqiang ] Key Laboratory of High Efficiency and Clean Manufacturing, School of Mechanical Engineering, Shand 更多
来源：Materials Science and Engineering C
摘要：Although many methods have been proposed to fabricate a micro/nanostructure on titanium surface for enhanced cellular responses to implants, it has been challenging to construct an orderly micro/nanostructure. In this study, an ordered structure of micropatterned TiO2 nanotubes was produced on titanium surface by the combined use of micro-milling and anodic oxidation. The surface properties of different modified titanium samples were investigated by field emission scanning electron microscopy, laser scanning microscope, X-ray diffraction, and contact angle goniometer. The corrosion resistance of different samples was evaluated by an electrochemical workstation. A series of cell experiments were performed to evaluate the responses of osteoblasts to the modified titanium substrates. The results indicated that the surface roughness and hydrophilicity of micro/nanostructured titanium remarkably increased compared to the polished titanium. In addition, the corrosion resistance of micro/nanostructured titanium samples was also improved in comparison to the polished titanium samples. More importantly, the proliferation and differentiation of cells were significantly promoted on micro/nanostructure titanium substrates. This study provides a promising method to construct a regular micro- and nano-structure on titanium surface for cytocompatibility improvement.
© 2018 Elsevier B.V.