标题:The overall safety evaluation of programmed cell death/programmed cell death ligand 1 (PD-1/PD-L1) treatment for lung cancer patients An updated systematic review and meta-analysis
作者:Shang, Heli; Zhang, Zewen; Feng, Alei; Yang, Xiaowei; Zhang, Shuisheng; Zhao, Yi; Zhu, Qingshan; Mao, Yantao; Liu, Kun; Tian, Yuan
作者机构:[Shang, Heli; Liu, Kun; Tian, Yuan] Shandong First Med Univ, Hosp 1, Shandong Prov Qianfoshan Hosp, Dept Radiotherapy Oncol, 16766 Jingshi Rd, Jinan 2 更多
通讯作者:Tian, Y
通讯作者地址:[Tian, Y]Shandong First Med Univ, Hosp 1, Shandong Prov Qianfoshan Hosp, Dept Radiotherapy Oncol, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R 更多
来源:MEDICINE
出版年:2019
卷:98
期:30
DOI:10.1097/MD.0000000000016439
关键词:lung cancer; meta-analysis; programmed cell death-1/programmed cell; death ligand 1; safety
摘要:Background: We performed the meta-analysis to evaluate the overall safety of programmed cell death-1 (PD-1) or ligand 1 (PD-L1) inhibitor treatment for lung cancer patients.; Method: Randomized controlled trials were collected according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Risk ratio (RR) of PD-1/PD-L1 inhibitor treatment-related death, treatment-related adverse events, any serious events, and any events leading to discontinuation were all taken into account for the final evaluation.; Results: Fourteen studies were collected for the meta-analysis. The RR of treatment-related death for PD-1/PD-L1 was significantly lower than that of the control group (RR=0.37, 95% confidence interval, CI: [0.21, 0.66]). Similar analysis results could also be seen for the RR of treatment-related adverse events and adverse events leading to discontinuation. When PD-1/PD-L1 was combined with chemotherapy, it increased the RR of adverse events leading to discontinuation (RR=1.68, 95% CI: [1.22, 3.32]). The RR of overall treatment-related adverse events was lower in nivolumab (PD-1) than that of the control group (nivolumab+ipilimumab) (RR=0.77, 95% CI: [0.65, 0.90]). Similar analysis results could also be seen in the RR of treatment-related adverse events for grade 3 to 5 and adverse events leading to discontinuation.; Conclusion: Compared with chemotherapy, RR of the treatment-related deaths associated with PD-1/PD-L1 inhibitor was significantly lower than that of the chemotherapy group, while it did not increase the RR when they were combined with chemotherapy or other drugs. When PD-1/PD-L1 was combined with chemotherapy, it increased the RR of adverse events leading to discontinuation.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070577811&doi=10.1097%2fMD.0000000000016439&partnerID=40&md5=fffe96f1b77c1564c02c773adc907cf9
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