标题：Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease
作者：Zhao, Ning; Guo, Fang-Fang; Xie, Ke-Qin; Zeng, Tao
作者机构：[Zhao, Ning; Xie, Ke-Qin; Zeng, Tao] Shandong Univ, Inst Toxicol, Sch Publ Hlth, 44 Wenhua West Rd, Jinan 250012, Shandong, Peoples R China.; [Guo, 更多
通讯作者地址：[Zeng, T]Shandong Univ, Inst Toxicol, Sch Publ Hlth, 44 Wenhua West Rd, Jinan 250012, Shandong, Peoples R China.
来源：CELLULAR AND MOLECULAR LIFE SCIENCES
关键词：Alcoholic liver disease; Nuclear factor erythroid-derived 2-like 2; (Nrf-2); Oxidative stress; p62; Autophagy
摘要：Alcoholic liver disease (ALD) remains to be a worldwide health problem. It is generally accepted that oxidative stress plays critical roles in the pathogenesis of ALD, and antioxidant therapy represents a logical strategy for the prevention and treatment of ALD. Nuclear factor erythroid-derived 2-like 2 (NFE2L2 or Nrf-2) is essential for the antioxidant responsive element (ARE)-mediated induction of endogenous antioxidant enzymes such as heme oxygenase 1 (HO-1) and glutamate-cysteine ligase [GCL, the rate-limiting enzyme in the synthesis of glutathione (GSH)]. Activation of Nrf-2 pathway by genetic manipulation or pharmacological agents has been demonstrated to provide protection against ALD, which suggests that targeting Nrf-2 may be a promising approach for the prevention and treatment of ALD. Herein, we review the relevant literature about the potential hepatoprotective roles of Nrf-2 activation against ALD.