标题:Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease
作者:Zhao, Ning; Guo, Fang-Fang; Xie, Ke-Qin; Zeng, Tao
作者机构:[Zhao, Ning; Xie, Ke-Qin; Zeng, Tao] Shandong Univ, Inst Toxicol, Sch Publ Hlth, 44 Wenhua West Rd, Jinan 250012, Shandong, Peoples R China.; [Guo, 更多
通讯作者:Zeng, T
通讯作者地址:[Zeng, T]Shandong Univ, Inst Toxicol, Sch Publ Hlth, 44 Wenhua West Rd, Jinan 250012, Shandong, Peoples R China.
来源:CELLULAR AND MOLECULAR LIFE SCIENCES
出版年:2018
卷:75
期:17
页码:3143-3157
DOI:10.1007/s00018-018-2852-6
关键词:Alcoholic liver disease; Nuclear factor erythroid-derived 2-like 2; (Nrf-2); Oxidative stress; p62; Autophagy
摘要:Alcoholic liver disease (ALD) remains to be a worldwide health problem. It is generally accepted that oxidative stress plays critical roles in the pathogenesis of ALD, and antioxidant therapy represents a logical strategy for the prevention and treatment of ALD. Nuclear factor erythroid-derived 2-like 2 (NFE2L2 or Nrf-2) is essential for the antioxidant responsive element (ARE)-mediated induction of endogenous antioxidant enzymes such as heme oxygenase 1 (HO-1) and glutamate-cysteine ligase [GCL, the rate-limiting enzyme in the synthesis of glutathione (GSH)]. Activation of Nrf-2 pathway by genetic manipulation or pharmacological agents has been demonstrated to provide protection against ALD, which suggests that targeting Nrf-2 may be a promising approach for the prevention and treatment of ALD. Herein, we review the relevant literature about the potential hepatoprotective roles of Nrf-2 activation against ALD.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048358853&doi=10.1007%2fs00018-018-2852-6&partnerID=40&md5=039e2a189b4b86d46658fb356a99bf5a
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