标题：Effect of Phacoemulsification Combined with Intraocular Lens Implantation on Inflammatory Factors, Oxidative Stress Response and Hemorheology in Diabetic Cataract Patients
作者：Gao, Xue; Hao, Linlin; Wang, Jiawei; Ma, Guangfeng; Zhang, Tonghe
作者机构：[Gao, Xue; Hao, Linlin; Wang, Jiawei; Ma, Guangfeng] Shandong Univ, Hosp 2, Dept Ophthalmol, Jinan, Shandong, Peoples R China.; [Zhang, Tonghe] Jina 更多
通讯作者地址：[Zhang, TH]Jinan Second Peoples Hosp, Dept Ophthalmol, Jinan 250021, Shandong, Peoples R China.
来源：JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
关键词：Phacoemulsification; Intraocular lens implantation; Diabetic cataract;; Inflammatory factor; Oxidative stress
摘要：Objective: To investigate the change on phacoemulsification combined with intraocular lens implantation on inflammatory factors IL-2, IL-6, hs-CRP, TNF-alpha; oxidative stress response indexes MDA, CAT, SOD, GSH-Px; peripheral blood hemorheologic index WHV, WMV, PV, PCV, FIB in diabetic cataract patients.; Study Design: An observational study.; Place and Duration of Study: Department of Ophthalmology, the Second Hospital of Shandong University, Jinan, China, from January 2015 to July 2017.; Methodology: One hundred anf fifty-two diabetic cataract patients (160 eyes) were randomly divided into observation group and control group, each with 76 cases (80 eyes). The control group was treated with conventional therapy, while the observation group was treated with phacoemulsification combined with intraocular lens implantation on the basis of conventional treatment. After one month of treatment, the patients were tested for IL-2, IL-6, hs-CRP, TNF-alpha, MDA, CAT, SOD, GSH-Px, WHV, WMV, PV, PCV, FIB.; Results: After one month of treatment, the levels of IL-2, IL-6, hs-CRP and TNF-alpha were lower in the observation group (p<0.001); the levels of SOD, GSH-Px and CAT were higher in the observation group (p<0.001), while MDA level was higher in the control group (p<0.001); the levels of WHV, WMV, PV were lower in the observation group (p<0.001), and there was no significant difference in the levels of PCV and FIB between the two groups (p = 0.794 and 0.838, respectively).; Conclusion: Phacoemulsification combined with intraocular lens implantation can improve the level of aqueous inflammatory factors and oxidative stress response indexes in diabetic cataract patients and improve their level of hemorheological indexest.