标题：Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis
作者：Qu, Xinyan; Li, Qingjun; Song, Yue; Xue, Anqi; Liu, Yuhua; Qi, Dongmei; Dong, Hongjing
作者机构：[Qu, Xinyan; Song, Yue; Xue, Anqi; Liu, Yuhua] Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Lab Immunol Environm & Hlth, Jinan, Sha 更多
通讯作者：Qi, DM;Dong, HJ
通讯作者地址：[Qi, DM]Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Shandong, Peoples R China;[Dong, HJ]Shandong Anal & Test Ctr, 19 Keyuan Rd, Jinan 25 更多
来源：JOURNAL OF PHARMACY AND PHARMACOLOGY
关键词：immune balance; inflammation; myricetin; ulcerative colitis
摘要：Objectives Myricetin is a bioactive compound in many edible plants with anti-inflammatory and anticarcinogenic activity. The current study aimed to determine the protective effects and mechanism of myricetin against ulcerative colitis (UC). Methods Myricetin was orally administered at doses of 40 and 80 mg/kg to C57BL/6 mice with UC induced using dextran sulfate sodium. The disease-associated index and colon length were determined at the end of the experiment, the proportion of Treg, Th1 and Th17 was analysed by cytometry, and cytokines were detected using ELISA. Key findings Myricetin (80 mg/kg) ameliorated the severity of inflammation in acute UC and significantly improved the condition. Myricetin (80 mg/kg) elevated the levels of IL-10 and transforming growth factor beta. In addition, the proportion of regulatory T cells significantly increased in mice in the myricetin treatment group. Conclusions Taking together, these results suggest that myricetin exhibits significant protective effects against UC and it could be used as a potential treatment for UC.