标题:25-hydroxyvitamin D is closely related with the function of the pancreatic islet β cells
作者:Guo J.; Xiao Z.; Xue X.; Liu X.; Lu Y.; Yin X.; Ma K.
作者机构:[Guo, J] Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China;[ Xiao, Z] Department of Endocrin 更多
通讯作者:Xiao, Z(xiaozhengda123@163.com)
通讯作者地址:[Xiao, Z] School of Medicine, Shandong University, Jinan, 250012, China;
来源:Pakistan Journal of Medical Sciences
出版年:2013
卷:29
期:3
DOI:10.12669/pjms.293.2982
关键词:Diabetes mellius; Pancreatic islet β Cell; Type 2; Vitamin D
摘要:Objectives: This study is to investigate the relationship between 25-Hydroxyvitamin D (25-OH-D) and pancreatic islet β cell function under different glucose tolerance statuses in China. Methodology: Totally, 180 patients with type 2 diabetes mellitus (DM group), 178 patients with impaired fasting glucose/impaired glucose tolerance (IFG/IGT group), and 160 normal control subjects (NGT group) were included to measure their body parameters and biochemical parameters. In oral glucose tolerance test, fasting serum 25-OH-D was assessed by the enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment for insulin resistance (Homa-IR), insulin acuity index (IAI), β-cell function index (Homa- BCF) as well as secretion index (IS) were determined. Results: The levels of 25-OH-D, IAI and Homa-BCF in the DM group and IFG/IGT group were significantly lower than that in NGT group (P < 0.05). Homa-IR in DM group and IFG/IGT group was significantly higher than that in the NGT group (P < 0.05). Pearson correlation analysis and partial correlation analysis showed that 25-OH-D was positively correlated with fasting insulin (FINS) and Homa-BCF (P < 0.05). Multiple stepwise regression analysis showed that 25-OH-D was one of the influential factors of pancreatic islet β cell function in patients with type 2 diabetes mellitus. Conclusions: Our results suggest that 25-OH-D is closely related with the function of the pancreatic islet β cells and is one of the influential factors of pancreatic islet β cell function.
收录类别:SCOPUS
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877609971&doi=10.12669%2fpjms.293.2982&partnerID=40&md5=95889590979d40bd7716483926c0dcf7
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