标题：Quorum sensing inhibitors: a patent review
作者：Tianyu Jiang;Minyong Li
作者机构：[Jiang, T] Shandong University, Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), Jinan, Shandong 25001 更多
通讯作者地址：[Li, MY]Shandong Univ, Sch Pharm, Dept Med Chem, Key Lab Chem Biol Nat Prod,MOE, Jinan 250012, Shandong, Peoples R China.
来源：Expert opinion on therapeutic patents
关键词：acyl-homoserine lactones;antibacterial;autoinducer-2;autoinducer peptides;biofilm;inhibitor;quorum sensing
摘要：Introduction: Quorum sensing (QS) is a cell-to-cell communication that regulates gene expression and coordinates their behavior in accordance with the cell population density as a result of discerning molecules termed autoin-ducers (Als). The processes that QS governed include biofilm formation, bacterial virulence, antibiotic production, competence, conjugation, swarming motility and sporulation. Three main QS Als are acyl-homoserine lactones, AI-2 and Al peptides. The attractive study of QS leads to an expansive number of QS inhibitors and approaches interfering with QS appearing.Areas covered: This review summarized the recent QS inhibitor-related patents published from 2009 to 2012. The authors have analyzed these patents and have provided an overview of QS inhibitors and their application. Expert opinion: The main strategies for QS inhibition related to the patents are disruption of the Al synthase, inactivation of the signal molecule, antagonism of the receptor and promotion of immune response to Al. Some of the natural or synthetic QS inhibitors display excellent activity to manipulate bacterial pathogenicity to offer significant potential in clinical therapy. However, more efforts are needed to be conducted to determine this form of communication to guide the development of QS inhibitors. Overall, QS is a suitable target for antimicrobial therapy and QS inhibitors are likely to lead to a renaissance of anti-virulence drugs without tolerance, which is the ultimate goal expected to achieve in this field.