标题：Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer
作者：Chen, Pengxiang; Wang, Cong; Cheng, Bo; Nesa, Effat Un; Liu, Yuan; Jia, Yibin; Qu, Yan; Jiang, Ziying; Han, Jie; Cheng, Yufeng
作者机构：[Chen, Pengxiang; Wang, Cong; Nesa, Effat Un; Liu, Yuan; Jia, Yibin; Qu, Yan; Jiang, Ziying; Cheng, Yufeng] Shandong Univ, Qilu Hosp, Dept Radiat Onco 更多
通讯作者地址：[Cheng, YF]Shandong Univ, Qilu Hosp, Dept Radiat Oncol, 107 West Wenhua Rd, Jinan 250012, Peoples R China.
来源：ONCOTARGETS AND THERAPY
关键词：non-small cell lung cancer; surgical treatment; serum albumin; plasma; fibrinogen; prognostic nutritional index; prognosis
摘要：Background: Evidence implies that preoperative plasma fibrinogen and serum albumin are associated with cancer prognosis. We aimed to explore the prognostic values of the score based on plasma fibrinogen and serum albumin levels (FA score) in non-small cell lung cancer (NSCLC), and to compare that with prognostic nutritional index (PNI).; Patients and methods: In all, 182 patients pathologically diagnosed with NSCLC were included in this study. Kaplan-Meier survival analysis and multivariate analysis were used in the prognostic analyses.; Results: High FA score was related to smoking (P=0.005), poor differential grade (P=0.002), and advanced T stage (P<0.001) and tumor, node, and metastases stage (P=0.011). Low PNI showed association with advanced T stage (P=0.030). Kaplan-Meier survival analysis indicated that high FA score and low PNI were associated with poor progression-free survival (PFS; for the FA score, P,<0.001; for PNI, P=0.001) and overall survival (OS; for the FA score, P<0.001; for PNI, P=0.013), respectively. Multivariate analysis revealed that FA score was an independent predictor for PFS (P=0.003) and OS (P=0.001) in NSCLC patients.; Conclusion: The FA score could act as a more promising prognostic predictor than PNI in NSCLC patients who underwent pneumonectomy.