标题：Meta-analysis of the association of maternal smoking and passive smoking during pregnancy with neural tube defects
作者：Meng, Xin; Sun, Yanxin; Duan, Wenhou; Jia, Chongqi
作者机构：[Meng, Xin; Sun, Yanxin; Duan, Wenhou; Jia, Chongqi] Shandong Univ, Dept Epidemiol, Jinan, Shandong, Peoples R China.
通讯作者地址：[Jia, CQ]Shandong Univ, Dept Epidemiol, Jinan, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
关键词：Meta-analysis; Neural tube defects; Pregnancy; Smoking
摘要：BackgroundIt is unclear whether the incidence of neural tube defects (NTDs) is greater with maternal smoking or with passive smoking during pregnancy.; ObjectivesTo compare the effects of smoking and passive smoking during pregnancy on the risk of NTDs.; Search strategyEnglish and Chinese databases were searched for relevant papers published before March 2017, using search terms including smoking and NTD.; Selection criteriaCase-control and cohort studies on the aforementioned association were included.; Data collection and analysisTwo authors independently extracted the original data. Meta-analyses were performed to assess the risks associated with smoking and passive smoking, followed by a comparison of the two pooled effect estimates. The I-2 statistic was used to examine between-study heterogeneity.; Main resultsThe final analysis included 23 articles representing 33 studies. The pooled odds ratio (OR) and 95% confidence interval (CI) for the risk of NTDs was 1.052 (0.907-1.220) with smoking and 1.898 (1.557-2.313) with passive smoking. Comparison of these ORs indicated that the risk of NTDs was higher with passive smoking than with smoking (OR 1.804, 95% CI 1.409-2.309).; ConclusionsCompared with smoking, exposure to passive smoking during pregnancy carries a higher risk of having infants with NTDs.; Compared with women who smoke during pregnancy, women exposed to passive smoking during pregnancy have a higher risk of having infants with neural tube defects.