标题:Current research on hyaluronic acid-drug bioconjugates
作者:Zhang, Haiqun; Huang, Siling; Yang, Xiaoye; Zhai, Guangxi
作者机构:[Zhang, Haiqun; Yang, Xiaoye; Zhai, Guangxi] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China.; [Huang, Siling] Blo 更多
通讯作者:Zhai, GX
通讯作者地址:[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Peoples R China.
来源:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
出版年:2014
卷:86
页码:310-317
DOI:10.1016/j.ejmech.2014.08.067
关键词:Hyaluronic acid; Pro-drug; Bioconjugates; Synthesis; Evaluation
摘要:Hyaluronic acid (HA) is a mucopolysaccharide acid composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. Based on numerous characteristics such as viscoelastic properties, water-binding ability, biocompatibility and non-immunogenicity, HA has been approved by FDA for biological and medical applications. In addition, multifarious receptors of HA like CD44, RHAMM and TSG6 are over-expressed on the surface of malignant cells, which play important roles in targeting ability. Bioconjugates linking drugs to HA could improve solubility, prolong half-life, provide active targeting capability and then increase the bioavailability of these coupled drugs by pro-drug strategy. Therefore, a large number of HA-drug bioconjugates have been studied. The purpose of this review was to summarize these HA-drug bioconjugates and further discuss synthetic methods and the relevant application in pharmaceuticals. (C) 2014 Elsevier Masson SAS. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:13
Scopus被引频次:9
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906829420&doi=10.1016%2fj.ejmech.2014.08.067&partnerID=40&md5=ee4d890fee390510e7b655634bf0c715
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