标题：Intestinal microbiome and autoimmune liver disease
作者机构：[Chi, Z.-C] Department of Gastroenterology, Qingdao Municipal Hospital, Affiliated Hospital of Shandong University Medical College, Qingdao, Shandong 更多
通讯作者地址：[Chi, Z.-C] Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, China;
来源：World Chinese Journal of Digestology
关键词：Autoimmune hepatitis; Innate immunity; Intestinal ecological imbalance; Mucosal barrier; Primary biliary cholangitis; Primary sclerosing cholangitis; Probiotics
摘要：At present, it has been proved that intestinal microbial-related disorders are involved in the development and progression of multi-organ system diseases. Intestinal microflora is the accumulation of microbial antigens and activated immune cells. Changes in the composition of intestinal microflora (biological disorders) can destroy the systemic immune tolerance of intestinal and symbiotic bacteria. Toll-like receptors in the intestine recognize microbial-related molecular patterns and T helper lymphocyte subpopulations that can cross-react with host antigens (molecular mimics). Activated enterogenous lymphocytes can migrate to lymph nodes, and enterogenous microbial antigens can migrate to extraintestinal sites. Inflammasomes can form in hepatocytes and hepatic stellate cells, which can drive inflammatory, immune-mediated and fibrotic responses. This article reviews and evaluates the role of intestinal microorganisms in the pathogenesis and treatment of autoimmune liver disease. © The Author(s) 2019.