标题：Biomedical application and controlled drug release of electrospun fibrous materials
作者：Cheng, Huiling; Yang, Xiaoye; Che, Xin; Yang, Mingshi; Zhai, Guangxi
作者机构：[Cheng, Huiling; Yang, Xiaoye; Zhai, Guangxi] Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China.; [Che, Xin; Yang, 更多
通讯作者地址：[Yang, MS]Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark;[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Ph 更多
来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
关键词：Electrospinning; Biomedical application; Membranes; Scaffolds;; Controlled drug release
摘要：Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. This review focuses on the recent advances in biomedical application of EFM, controlled drug release from EFM and devices for producing sophisticated EFM. The processing parameters which influence the physicochemical properties of the resulting EFM are also summarized as well as scaling up techniques for mass production of EFM.