标题：Recent advances in the medicinal chemistry of group II and group III mGlu receptors
作者：Jin, Chaobin; Ma, Shutao
作者机构：[Jin, Chaobin; Ma, Shutao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44,West Culture Rd, Jinan 250012, Peoples 更多
通讯作者地址：[Ma, ST]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44,West Culture Rd, Jinan 250012, Peoples R China.
摘要：Metabotropic glutamate receptors (mGlu receptors) belong to the G-protein-coupled receptors superfamily. They are divided into three groups, in which group II and group III belong to presynaptic receptors that negatively modulate glutamate and gamma-aminobutyric acid (GABA) release when activated. In this review, we introduce not only the functions of mGlu receptors, but also the group II and group III allosteric modula-tors and agonists/antagonists reported over the past five years according to a classification of their structures, with a specific focus on their biological activity and selectivity. In particular, the structure of these compounds and the future directions of ideal candidates are highlighted.