标题:Recent advances in the medicinal chemistry of group II and group III mGlu receptors
作者:Jin, Chaobin; Ma, Shutao
作者机构:[Jin, Chaobin; Ma, Shutao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44,West Culture Rd, Jinan 250012, Peoples 更多
通讯作者:Ma, ST
通讯作者地址:[Ma, ST]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44,West Culture Rd, Jinan 250012, Peoples R China.
来源:MEDCHEMCOMM
出版年:2017
卷:8
期:3
页码:501-515
DOI:10.1039/c6md00612d
摘要:Metabotropic glutamate receptors (mGlu receptors) belong to the G-protein-coupled receptors superfamily. They are divided into three groups, in which group II and group III belong to presynaptic receptors that negatively modulate glutamate and gamma-aminobutyric acid (GABA) release when activated. In this review, we introduce not only the functions of mGlu receptors, but also the group II and group III allosteric modula-tors and agonists/antagonists reported over the past five years according to a classification of their structures, with a specific focus on their biological activity and selectivity. In particular, the structure of these compounds and the future directions of ideal candidates are highlighted.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016100337&doi=10.1039%2fc6md00612d&partnerID=40&md5=d470a961345a4b0a7f5a8f072bce169c
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