标题:Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis
作者:Liu, Na; Wu, Cong; Yu, Jin-hai; Zhu, Kong-kai; Song, Mei-na; Yang, Feng-ying; Feng, Run-liang; Zhang, Yu-ying; Chang, Wen-qiang; Zha 更多
作者机构:[Liu, Na; Wu, Cong; Yu, Jin-hai; Zhu, Kong-kai; Song, Mei-na; Yang, Feng-ying; Feng, Run-liang; Zhang, Yu-ying; Zhang, Hua] Univ Jinan, Sch Biol Sci & 更多
通讯作者:Zhang, H
通讯作者地址:[Zhang, H]Univ Jinan, Sch Biol Sci & Technol, 336 West Rd Nan Xinzhuang, Jinan 250022, Shandong, Peoples R China.
来源:BIOORGANIC CHEMISTRY
出版年:2019
卷:92
DOI:10.1016/j.bioorg.2019.103196
关键词:Sigesbeckia orientalis; Germacrane; Sesquiterpenoids; Cytotoxicity
摘要:Eleven new highly oxygenated germacrane-type sesquiterpenoids (1-11) and 16 known analogues (12-27) were isolated from the aerial parts of Sigesbeckia orientalis. Their structures, including absolute configurations, were determined by comprehensive spectroscopic methods especially NMR and ECD analyses. Compounds 13, 21 and 23 possessing an 8-methacryloxy group showed stronger in vitro cytotoxicity against human A549 and MDA-MB-231 cancer cell lines than other co-metabolites, with IC50 values ranging from 6.02 to 10.77 mu M comparable to the positive control adriamycin.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070881249&doi=10.1016%2fj.bioorg.2019.103196&partnerID=40&md5=deed6b4c017e607928fd34be5de89f07
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