标题:Meta-analysis of the correlation between the TNF-α 308G/A polymorphism and polycystic ovary syndrome
作者:Liu X.B.; Deng X.H.; Zhou B.; Zhang L.; Niu X.M.
作者机构:[Liu, X.B] Department of Reproduction and Genetics, Central Hospital of Taian, Taian, China;[ Deng, X.H] Reproduction Medicine Center, Qilu Hospital, 更多
通讯作者:Deng, XH(dengxiaohuisd@163.com)
通讯作者地址:[Deng, X.H] Reproduction Medicine Center, Qilu Hospital, Shandong UniversityChina;
来源:Genetics and Molecular Research
出版年:2016
卷:15
期:2
DOI:10.4238/gmr.15027923
关键词:Meta-analysis; Polycystic ovary syndrome; Polymorphism; Tumor necrosis factor alpha
摘要:Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α 308G/A polymorphism and susceptibility to PCOS. A systematic electronic search of PubMed and Embase databases was conducted using specific inclusion criteria. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated, and all statistical analyses were performed using STATA 12.0. The results of our meta-analysis showed no significant association between the TNF-α 308G/A polymorphism and PCOS risk (AA vs GG: OR = 0.80, 95%CI = 0.31-2.08; AG vs GG: OR = 1.03, 95%CI = 0.59-1.81; dominant model: OR = 1.02, 95%CI = 0.60-1.71; recessive model: OR = 0.87, 95%CI = 0.35-2.16). Based on the statistical data, our meta-analysis indicates that the TNF-α 308G/A sequence variation may be not related to PCOS susceptibility. Further large and well-designed studies are needed to confirm this conclusion. © FUNPEC-RP.
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975299348&doi=10.4238%2fgmr.15027923&partnerID=40&md5=a057f531a71eb9f4b5c2902cc31bc06c
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