标题:Synthesis and Release Behavior of a Hybrid of Camptothecin Intercalated Dodecyl Sulfate Modified Layered Double Hydroxide
作者:Li Yan; Du Na; Hou Wanguo; Liu Shaojie
作者机构:[Li, Y] Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan, 250100, China;[ Du, N] Key Laboratory of 更多
通讯作者:Liu, S(shaojieliu@sdu.edu.cn)
通讯作者地址:[Liu, SJ]Shandong Univ, Natl Engn Res Ctr Colloidal Mat, Jinan 250100, Peoples R China.
来源:高等学校化学研究(英文版)
出版年:2014
卷:30
期:1
页码:137-143
DOI:10.1007/s40242-014-3284-y
关键词:Layered double hydroxide(LDH);Camptothecin;Hybrid;Controlled release
摘要:The intercalation of a non-ionic and poorly water-soluble drug, camptothecin(CPT), into dodecyl sulfate (DS) modified layered double hydroxide(LDH) was carried out via a secondary intercalation method to obtain a CPT-DS-LDH hybrid. The in vitro CPT release eFxaminations from the hybrid show that the hybrid can well control the release of CPT, which indicates that the hybrid is a potential drug controlled-release system. Moreover, the intercalation kinetics of CPT into the DS modified LDH fits for the pseudo-second-order model. And the release kinetic process of CPT from the CPT-DS-LDH hybrid at pH=4.8 can be described with pseudo-first-order model, while that at pH=7.2 can be described with both pseudo-first-order model and pseudo-second-order model. Meanwhile, the release mechanism of CPT from the CPT-DS-LDH hybrid was discussed.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:5
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893338592&doi=10.1007%2fs40242-014-3284-y&partnerID=40&md5=cb4ffadf92e65d1aa72a523584f334f9
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