标题：Synthesis and Release Behavior of a Hybrid of Camptothecin Intercalated Dodecyl Sulfate Modified Layered Double Hydroxide
作者：Li Yan; Du Na; Hou Wanguo; Liu Shaojie
作者机构：[Li, Y] Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan, 250100, China;[ Du, N] Key Laboratory of 更多
通讯作者地址：[Liu, SJ]Shandong Univ, Natl Engn Res Ctr Colloidal Mat, Jinan 250100, Peoples R China.
关键词：Layered double hydroxide(LDH);Camptothecin;Hybrid;Controlled release
摘要：The intercalation of a non-ionic and poorly water-soluble drug, camptothecin(CPT), into dodecyl sulfate (DS) modified layered double hydroxide(LDH) was carried out via a secondary intercalation method to obtain a CPT-DS-LDH hybrid. The in vitro CPT release eFxaminations from the hybrid show that the hybrid can well control the release of CPT, which indicates that the hybrid is a potential drug controlled-release system. Moreover, the intercalation kinetics of CPT into the DS modified LDH fits for the pseudo-second-order model. And the release kinetic process of CPT from the CPT-DS-LDH hybrid at pH=4.8 can be described with pseudo-first-order model, while that at pH=7.2 can be described with both pseudo-first-order model and pseudo-second-order model. Meanwhile, the release mechanism of CPT from the CPT-DS-LDH hybrid was discussed.