标题:A novel IgM-H-Ficolin complement pathway to attack allogenic cancer cells in vitro
作者:Lei, Xiaoying; Liu, Chaoxu; Azadzoi, Kazem; Li, Cuiling; Lu, Fan; Xiang, An; Sun, Jianbin; Guo, Yanhai; Zhao, Qingchuan; Yan, Zhen; 更多
作者机构:[Lei, Xiaoying; Xiang, An; Sun, Jianbin; Guo, Yanhai; Yan, Zhen] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacogen, State Key Lab Canc Biol, Xian 71003 更多
通讯作者:Yang, JH
通讯作者地址:[Yang, JH]Boston Univ, Dept Surg, VA Boston Healthcare Syst, Sch Med, Boston, MA 02130 USA.
来源:SCIENTIFIC REPORTS
出版年:2015
卷:5
DOI:10.1038/srep07824
摘要:The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by activating the complement lectin pathway or a primitive opsonophagocytosis. It remains unknown whether serum IgMs interplay with ficolins in cancer immunosurveillance. Here we report a natural cancer killing of different types of cancer cells by sera from a healthy human population mediated by a novel IgM-H-ficolin complement activation pathway. We demonstrate for the first time that H-ficolin bound to a subset of IgMs in positive human sera and IgM-H-ficolin deposited on cancer cells to activate complement attack in cancer cells. Our data suggest that the IgM-H-ficolin -mediated complement activation pathway may be another defensive strategy for human cancer immunosurveillance.
收录类别:SCOPUS;SCIE
WOS核心被引频次:5
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938147014&doi=10.1038%2fsrep07824&partnerID=40&md5=5a7141c7a6a4c3b8e10e7adde2ade5b6
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