标题：Novel nanovectors as the liver target molecular: MRI contrast agents
作者：Zhang N.; Chen Z.
作者机构：[Zhang, N] School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, 250012 Ji'nan, China;[ Chen, Z] School of Pharmaceutical Science, 更多
通讯作者地址：[Zhang, N] School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, 250012 Ji'nan, China;
来源：Gadolinium: Compounds, Production and Applications
摘要：Accurate diagnosis in early stage is vital for the treatment of hepatocellular carcinoma(HCC). Contrast material-enhanced dynamic magnetic resonance imaging (MRI) performed with extracellular contrast agents such as gadolinium chelates is considered useful for detecting and characterizing focal liver lesions. However, the sensitivity and specificity of conventional MRI contrast agents are far from satisfaction for the detection and characterization of benign and malignant focal liver lesions in early stage. The novel molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue are highly desired. The developing nanotechnology provides an unprecedented opportunity for the diagnostic detection rate of HCC, and cell-surface receptor-targeted nanotenology provide improving specificity of the detection of focal liver lesions. In order to maximize lesion detection and characterization, novel gadolinium chelates loaded nanovectors include the solid lipid nanoparticles, nanocomplexes and polymeric nanoparticles has been used as biocompatible molecular MRI contrast agent. In this chapter, we would discuss the preparation, characterization and the advantages/ disadvantages of these novel nanovectors using as molecular MRI contrast agents. Furthermore, liver target nanovectors aimed at improving the diagnostic accuracy of liver MRI by targeting additional features of focal liver lesions would be highlighted. © 2010 by Nova Science Publishers, Inc. All rights reserved.