标题:Polyphosphoric Acid-Mediated, One-Pot, Novel Reactions to Build Polymethoxyarylnaphthalene Lignans
作者:Zhao, Guilong; Zhan, Fuxu; Wang, Zhifeng; Xu, Weiren; Wang, Yuli; Liu, Wei; Tang, Lida; Wang, Jianwu
作者机构:[Zhao, Guilong; Xu, Weiren; Wang, Yuli; Liu, Wei] Tianjin Inst Pharmaceut Res, Tianjin Key Lab Mol Design & Drug Discovery, Tianjin 300193, Peoples R 更多
通讯作者:Zhao, GL
通讯作者地址:[Zhao, GL]Tianjin Inst Pharmaceut Res, Tianjin Key Lab Mol Design & Drug Discovery, Tianjin 300193, Peoples R China.
来源:SYNTHETIC COMMUNICATIONS
出版年:2010
卷:40
期:3
页码:351-360
DOI:10.1080/00397910902978023
关键词:Arylnaphthalene lignan; Friedel-Crafts acylation; one pot;; polyphosphoric acid; synthesis; x-ray diffraction
摘要:The one-pot reaction of succinic anhydride with 1,2-dimethoxybenzene furnished two structurally complicated polymethoxyarylnaphthalene lignans, polymethoxyarylnaphthol 1 as the minor product and polymethoxynaphtho[1,2-b]oxacycloheptatrienone 2 as the major product, in the presence of a small amount of polyphosphoric acid (PPA) as catalyst at 140 degrees C and yielded 2 as a single product in good yield when a large amount of PPA as solvent was employed at 60-80 degrees C. The novel structures of 1 and 2 were elucidated from 1H NMR, 13C NMR, infrared (IR), and Electrospray ionization-mass spectrometry (ESI-MS) and further confirmed by x-ray diffractions. The possible mechanisms for the formation of 1 and 2 were also proposed.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-73949093068&doi=10.1080%2f00397910902978023&partnerID=40&md5=2f21988379c30bd35dae9f7b1d684809
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