标题:Recent Advances in the Research of Heterocyclic Compounds as Antitubercular Agents
作者:Mi Yan;Shutao Ma
作者机构:[Yan, M] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong Un 更多
通讯作者:Yan, M
通讯作者地址:[Yan, M]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44 W Culture Rd, Jinan 250012, Peoples R China.
来源:ChemMedChem
出版年:2012
卷:7
期:12
页码:2063-2075
DOI:10.1002/cmdc.201200339
关键词:antimycobacterial agents;heterocycles M. tuberculosis;MDR-TB;resistance
摘要:Tuberculosis (TB) is a major health problem, with approximately one-third of the world\'s population infected with Mycobacterium tuberculosis, eight million people in the active disease state, and two million dying annually. Furthermore, the prevalence of TB/HIV co-infection, and the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) have further aggravated the spread of this disease and thus mortality by it. There is an urgent need for novel antitubercular agents with improved properties, such as lower toxicity, shortened duration of therapy, rapid bactericidal action, and enhanced activity against MDR strains. Fortunately, a number of new potential antitubercular candidate drugs with heterocyclic rings, which are most likely to be effective against resistant strains, have entered clinical trials in recent years. This review highlights recent advances in the research of novel heterocyclic compounds, with particular focus on their antimycobacterial activity, mechanisms of action, toxicity, and structure-activity relationships (SARs).
收录类别:SCOPUS;SCIE
WOS核心被引频次:16
Scopus被引频次:16
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870267041&doi=10.1002%2fcmdc.201200339&partnerID=40&md5=7774bf3ab9134beaf96cadcf0f3bab7d
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