标题:The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology
作者:Shen,T.;Li,G.-H.;Wang,X.-N.;Lou,H.-X.
作者机构:[Shen, T] School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, China;[ Li, G.-H] Department of Pharmacy, Jinan M 更多
通讯作者:Lou, HX
通讯作者地址:[Lou, HX]Shandong Univ, Sch Pharmaceut Sci, 44 W Wenhua Rd, Jinan 250012, Peoples R China.
来源:Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs
出版年:2012
卷:142
期:2
页码:319-330
DOI:10.1016/j.jep.2012.05.025
关键词:Anti-inflammatory;Antiproliferative;Biological activity;Commiphora;Myrrh;Phytochemistry;Steroids;Terpenoids;Toxicology
摘要:Ethnopharmacological relevance: The resinous exudates of the Commiphora species, known as \'myrrh\', are used in traditional Chinese medicine for the treatment of trauma, arthritis, fractures and diseases caused by blood stagnation. Myrrh has also been used in the Ayurvedic medical system because of its therapeutic effects against inflammatory diseases, coronary artery diseases, gynecological disease, obesity, etc. Aim of the review: Based on a comprehensive review of traditional uses, phytochemistry, pharmacological and toxicological data on the genus Commiphora, opportunities for the future research and development as well as the genus\' therapeutic potential are analyzed. Methods: Information on the Commiphora species was collected via electronic search (using Pubmed, SciFinder, Scirus, Google Scholar and Web of Science) and a library search for articles published in peer-reviewed journals. Furthermore, information also was obtained from some local books on ethnopharmacology. This paper covers the literature, primarily pharmacological, from 2000 to the end of December 2011. Results: The resinous exudates from the bark of plants of the genus Commiphora are important indigenous medicines, and have a long medicinal application for arthritis, hyperlipidemia, pain, wounds, fractures, blood stagnation, in Ayurvedic medicine, traditional Chinese medicine and other indigenous medical systems. Phytochemical investigation of this genus has resulted in identification of more than 300 secondary metabolites. The isolated metabolites and crude extract have exhibited a wide of in vitro and in vivo pharmacological effects, including antiproliferative, antioxidant, anti-inflammatory and antimicrobial. The bioactive steroids guggulsterones have attracted most attention for their potent hypolipidemic effect targeting farnesoid X receptor, as well as their potent inhibitory effects on tumor cells and anti-inflammatory efficiency. Conclusions: The resins of Commiphora species have emerg
收录类别:SCOPUS;SCIE
WOS核心被引频次:57
Scopus被引频次:66
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862837838&doi=10.1016%2fj.jep.2012.05.025&partnerID=40&md5=5e0bb4b73b125b78f9635cdf2bd4d166
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