标题：Comprehensive assessment of tranexamic acid during orthognathic surgery: A systematic review and meta-analysis of randomized, controlled trials
作者：Zhao, Haoming; Liu, Shaopeng; Wu, Zuping; Zhao, Huaqiang; Ma, Chuan
作者机构：[Zhao, Haoming; Liu, Shaopeng; Wu, Zuping; Zhao, Huaqiang; Ma, Chuan] Shandong Univ, Sch Stomatol, Jinan 250012, Shandong, Peoples R China.; [Zhao, 更多
通讯作者：Ma, C;Zhao, H
通讯作者地址：[Ma, C]Shandong Univ, Sch Stomatol, Jinan 250012, Shandong, Peoples R China;[Zhao, H]Shandong Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, 44 W 更多
来源：JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
关键词：Orthognathic surgery; Tranexamic acid (TXA); Blood loss; Operation time;; Haematocrit; Quality of surgical field
摘要：The objective of this study was to comprehensively assess the use of tranexamic acid (TXA) during orthognathic surgery. A systematic review and meta-analysis of randomized controlled trials addressing these issues were carried out. Three electronic databases, included PubMed, Web of Science, and Cochrane Library, were searched until April 30, 2018. Eligible studies were restricted to randomized, controlled trials (RCTs). Weighted mean differences (WMD) for blood loss, operation time, haematocrit, quality of surgical field, and odds ratio (OR) for transfusion rates were pooled for the included studies. Eight randomized, controlled trials were included for analysis. Compared with the control group, the TXA group showed a reduction in intraoperative blood loss of 165.03 ml (p < 0.00001; 95% CI, -200.93 to -129.13 ml), a reduction in the drop of haematocrit of 2.32 g/dl (p < 0.00001; 95% CI, -3.38 to -1.26 g/dl), and an improved quality of surgical field (p < 0.00001; MD, -1.01; 95% CI, -1.23 to -0.80). Tranexamic acid has a limited effect on reducing operative time (p < 0.00001; MD, -16.18 min; 95% CI, -19.60 to -12.75 min) and on decreasing the transfusion rates (p = 0.02; OR = 0.33; 95% CI, 0.13 to 0.83). (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.