标题：Retinal toxicity associated with high dose of meclofenamic acid
作者：Hui Sun;Ying Wen;Nannan Ning
作者机构：Department of Physiology, Shandong University School of Medicine, Jinan, China;Shandong Shierming Ophthalmology Hospital, Jinan
通讯作者地址：[Li, JX]Shandong Univ, Sch Med, Dept Physiol, 44 Wenhua Xi Rd, Jinan 250012, Peoples R China.
来源：Drug and Chemical Toxicology
关键词：Electroretinography;NSAID;retinal toxicity;side effect;vision
摘要：Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications because they provide effective relief of chronic pain and inflammation through inhibition of cyclooxygenase (COX). However, visual side effects also have been reported, such as temporary blindness, visual field defect, blurred vision, scotomata, and color vision changes subsequent to short- or long-term use. Our aim was to investigate the effect of a high dose of meclofenamic acid (MFA) on the retina. In our study, we applied electroretinography (ERG) and histologic examination to study functional and morphological damage of the retina in rabbits after MFA treatment. We reveal that MFA markedly decreased the amplitudes of b-wave of Rod-response and a- and b-wave of the scotopic standard combined ERG, respectively, and induced morphological destruction of the retina, especially photoreceptor cells. We conclude that a high dose of MFA causes retinal toxicity and impairs visual transduction. These findings may explain, at least partially, the vision problems of certain clinically used NSAIDs.