标题：Discovery and Optimization of NAD(+)-Dependent DNA Ligase Inhibitors as Novel Antibacterial Compounds
作者：Bi, Fangchao; Ma, Ruixin; Ma, Shutao
作者机构：[Bi, Fangchao; Ma, Shutao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44 West Culture Rd, Jinan 250012, Peoples 更多
通讯作者地址：[Ma, ST]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, 44 West Culture Rd, Jinan 250012, Peoples R China.
来源：CURRENT PHARMACEUTICAL DESIGN
关键词：DNA ligases; LigAs; inhibitors; antibacterial; HTS; VS
摘要：With the serious problem of multiple drug resistance to antibiotics among pathogenic bacteria spreading across the world over the past 30 years, it is crucial to search for novel inhibitors with distinct modes of action from diverse chemical classes. NAD(+)-dependent DNA ligases (LigAs) are essential enzymes in bacteria, vital for DNA replication and repair. Additionally, LigAs exclusively exist in eubacteria and some viruses and are not found in humans. Those enzymes have therefore been identified as attractive antibacterial drug targets. In this review we explore the discovered inhibitors of LigA through high-throughput screening or virtual screening respectively and their further structure optimization.