标题：A novel stimulus-responsive temozolomide supramolecular vesicle based on host-guest recognition
作者：Ma, Mingfang; Kong, Lingdong; Du, Zhongyu; Xie, Zengyang; Chen, Lin; Chen, Ruijiao; Li, Zhenquan; Liu, Jun; Li, Zhaolou; Hao, Aiyou
作者机构：[Ma, Mingfang; Kong, Lingdong; Du, Zhongyu; Xie, Zengyang; Chen, Lin; Chen, Ruijiao; Li, Zhenquan; Liu, Jun; Li, Zhaolou] Jining Med Univ, Coll Basic 更多
通讯作者：Ma, Mingfang;Ma, MF;Hao, AY;Hao, AY
通讯作者地址：[Ma, MF]Jining Med Univ, Coll Basic Med, Lab New Antitumor Drug Mol Design & Synth, Jining 272067, Peoples R China;[Hao, AY]Shandong Univ, Minist Educ 更多
来源：COLLOID AND POLYMER SCIENCE
关键词：Temozolomide; Vesicle; Hydroxypropyl-beta-cyclodextrin; Drug delivery
摘要：Temozolomide is a potent chemotherapeutic agent for glioblastoma multiforme treatment. However, its low aqueous solubility and short half-life (only about 1.8h) in plasm limit its clinical therapeutics. Herein, a supramolecular vesicle based on hydroxypropyl--cyclodextrin and temozolomide was firstly constructed by elaborate design and preparation, which can load temozolomide into membranous layer of vesicle effectively. The morphologies and diameters of this temozolomide-loaded vesicle were characterized through transmission electron microscope, scanning electron microscope, and dynamic light scattering. The possible vesicle formation mechanism was further studied by X-ray diffraction, Fourier transform infrared spectrum, ultraviolet-visible spectroscopy, H-1 nuclear magnetic resonance, and 2D nuclear magnetic resonance (ROSEY). Finally, the stimulus responsiveness of this vesicle was studied. Temozolomide can be released from the membrane of the vesicle once copper ions were dropped into the vesicle solution. Herein, a novel supramolecular vesicle based on hydroxypropyl-beta-cyclodextrin and temozolomide was constructed by elaborate design and preparation, which can load temozolomide into membranous layer of vesicle effectively. Moreover, hydroxypropyl-beta-cyclodextrin/temozolomide vesicles exhibit sensitive stimulus responsiveness to copper ions since vesicles will change to irregular aggregates when copper ions are added into this vesicle system.